Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Association Analysis of Polymorphisms in TOMM40, CR1, PVRL2, SORL1, PICALM, and 14q32.13 Regions in Colombian Alzheimer Disease Patients. 27023435 2017
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. 16325427 2006
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Peroxisomal proliferation protects from beta-amyloid neurodegeneration. 16204253 2005
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). 12192006 2002
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Copper reduction by copper binding proteins and its relation to neurodegenerative diseases. 12572668 2003
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease. 16969627 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Vitamin E protects nerve cells from amyloid beta protein toxicity. 1497677 1992
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis. 19286555 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses. 29107063 2018
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease. 21209907 2010
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development. 30319691 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. 30320580 2018
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study. 20640797 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. 16492752 2006
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.500 Biomarker disease CTD_human Elevated serum pesticide levels and risk for Alzheimer disease. 24473795 2014
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting Aβ Accumulation. 25714973 2015
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human "How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD." 17430250 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro. 15993441 2005
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation. 12852432 2003
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. 25352456 2015
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity. 20111991 2010
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease. 12746438 2003
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. 18583042 2008
Entrez Id: 351
Gene Symbol: APP
APP 		0.500 Biomarker disease CTD_human Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease. 16266835 2006